nanoScan SPECT/CT

Powerful high sensitivity, high resolution and fully integrated small animal SPECT/CT system for imaging a wide range of animal species; from mice to monkeys

The nanoScan SPECT/CT is a unique, patented multi-modality system that allows 3D functional imaging of SPECT tracers at sub-half-mm resolution level. The integrated, ultra-fast, low-dose and variable FOV micro-CT provides automatically registered anatomical information for fusion and corrections. The nanoScan SPECT/CT system is a high-speed, high resolution device for both focused and whole body imaging of small animals (e.g. mice and rats, ferrets, minipigs, rabbits, and even smaller non-human primates). The preclinical SPECT/CT system supports quantitative dynamic imaging with full list mode acquisition format. Gated possibilities are offered for both modalities.

Looking for exceptional soft-tissue contrast, and anatomical information obtained with non-ionizing radiation in the preclinical imaging field? Read more about our nanoScan SPECT/MRI.

Summary of Key Benefits

• Continuous leadership in preclinical SPECT technology
  • Non-multiplexed M³pinhole™ apertures (multi-pinhole, multi-size, multi-focal), up to 100 pinholes; easily replaceable; whole-body mouse and rat
  • By using 4 large broadband detectors and M³ SPECT technology the nanoScan SPECT/CT offers offers outstanding space-bandwidth product and detector efficiency further increasing sensitivity and improving spatial resolution.
  • Exceptional performance: Up to 10,000 cps/MBq sensitivity @ sub-millimeter resolution / Up to 0.275 mm resolution
  • Ultra-fast 4D/5D list mode dynamic imaging by static or rotational modes with stationary and helical scans
  • The ONLY system to apply both CT-based attenuation and scatter correction - especially important for quantitative low-energy isotope studies
  • The ONLY small animal SPECT that can image Mice and Monkeys^(*) (* with parallel hole collimators)
• Compact and easy-to-use design
• CT is used for anatomical reference and enhances SPECT image quality by attenuation and scatter correction

System Design

• Spiral mode with extended axial field of view of 28 cm for both modalities
• Fully automated animal positioning based on CT scout; manual adjustment is also supported
• System is equipped with remote access possibility for service and remote diagnostics
• Safety switches are located in both the acquisition and control room allowing immediate stop of the examination
• 17” touchscreen monitor on the gantry which allows the user to control bed movements, gantry rotation, positioning for CT zoom and positioning related calibrations and settings

Summary of Key Benefits for CT

The X-ray CT alone is a powerful whole-body imaging system in its own right. Provides the largest variety of species imaging in industry, including larger animals or a whole body mouse scan in one bed position. Offering a very large detector surface and large bore with helical scanning capability, variable zoom (up to 8) and high power X-ray source (up to 80W).

• Broadest range of CT applications: Ultrafast and ultralow dose CT with variable zoom up to x7.6 magnification to visualize even the smallest organs or in-vitro samples up to 120mm FOV
• Perform a whole-body mouse scan in 2 minutes - have the result instantly with 80 micron voxel size
• Closest source-object distance for in-vivo: extra small objects imaging

Tomographic information is ready at the end of scan*: on the fly real time reconstruction is enabled by multi-GPUs (*: for general settings)

Lower X-ray exposure dose to animals and faster data acquisition due to stronger X-ray tube, increased detector area, sensitivity and better filtering

Fully automated calibration processes

Improved safety functions (gantry rotation position is stored, optimized x-ray ramp-up and run-up to ensure prolonged tube lifetime)

Summary of Key Benefits for SPECT

Mediso Ultra High Performance (UHP) Detector

• More than doubled crystal volume: 50% larger detector area & 50% thicker crystal (compared to NanoSPECT/CT)
• Fully digital premium electronics: digital 1 ADC/PMT non-Anger detector electronics
• 4 NaI(Tl) single 28x28cm crystal detectors; crystal thickness 9.5mm; detector FOV 27x27cm
• Number of photomultiplier tubes: 144 (for 4 heads)
• Fully digital: digital 1 ADC/PMT non-Anger detector electronics

Mediso multi-focal multi-size multiple pinhole apertures (M3-pinhole™)

• Rectangular apertures have variable aperture size in one plate
• Multifocal geometry
• Non-overlapping projections
• Select the appropriate aperture for the application: whole-body mouse, whole-body rat, ultra-high sensitivity or resolution apertures
• Fast and easy replacement of apertures

Further Information

General Scientific Literature

• Meikle, Steven R., Peter Kench, Michael Kassiou, and Richard B. Banati. "Small Animal SPECT and Its Place in the Matrix of Molecular Imaging Technologies." Physics in Medicine and Biology 50, no. 22 (November 21, 2005): R45. doi:10.1088/0031-9155/50/22/R01. | NCBI link
• Franc, Benjamin L., Paul D. Acton, Carina Mari, and Bruce H. Hasegawa. "Small-Animal SPECT and SPECT/CT: Important Tools for Preclinical Investigation." Journal of Nuclear Medicine 49, no. 10 (October 1, 2008): 1651–1663. doi:10.2967/jnumed.108.055442. | NCBI link

Cited Literature

• ^↩ Barrett, Harrison H., and William C. J. Hunter. "Detectors for Small-Animal SPECT I." In Small-Animal Spect Imaging, edited by Matthew A. Kupinski and Harrison H. Barrett, 9–48. Springer US, 2005.
  The space-bandwidth product is given by the area of the detector divided by the area of the detector’s point-spread function (PSF), and is thus a way to characterize the number of independent locations to which a detector can assign events.

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