nanoScan PET/CT

Best resolution in the industry with high sensitivity: fully integrated, large FOV small animal PET/CT system for quantitative in vivo imaging with complete animal handling system

The nanoScan PET/CT preclinical in vivo imager offers user-friendly imaging and the broadest range of supported applications in one simple to use, high-end PET/CT system. The nanoScan PET/CT is equipped with an imaging technology that is widely considered to have most advanced PET and CT detector construction, data processing and reconstruction chain in the industry.

The preclinical nanoScan PET/CT ensures achieving the best imaging resolution as well as the highest sensitivity with unmatched image quality in the whole body of the animal.

Looking for exceptional soft-tissue contrast, and anatomical information obtained with non-ionizing radiation in the preclinical imaging field? Read more about our nanoScan PET/MRI.

Summary of Key Benefits

Highest resolution PET subsystem with outstanding quantification:

• ≤ 0.7 mm resolution (measured with Derenzo phantom and reconstructed with Tera-Tomo™ 3D PET engine)
• Uniform resolution over the entire FOV
• Quantitative accuracy better than 97%

Imaging capability for larger animals, such as monkeys with 16cm gantry bore diameter and 12 cm Transaxial Field of View (TFOV) in both modalities

Open tunnel PET/CT construction

• Tail injection and blood sampling with animal in the axial FOV - ideal for dynamic PET applications
• Backdoor access to the animal with re-sealable door opening

Fully integrated with MultiCell™, the complete small animal environment system to provide vital support functions to lab animals during the whole application process

Integrated cardiac and respiratory gating capabilities for both PET and CT

Standalone use is possible for each modality

Fully compatible with nanoScan® PET/MRI, NanoSPECT/CT® and NanoPET/CT®

Compliant with CE, DICOM, CFR 21 industry standards

Compact and easy-to-use design

System Design

• Spiral mode with extended axial field of view of 30 cm for both modalities
• accessability to the animal during scanning: Flat front cover with minimized dead area in both axial and transaxial directions
• Fully automated animal positioning based on CT scout; manual adjustment is also supported
• System is equipped with remote access possibility for service and remote diagnostics
• Safety switches are both in the acquisition and control room allowing immediate stop of the examination
• 17” touchscreen monitor on the gantry which allows the user to control bed movements, gantry rotation, positioning for CT zoom and positioning related calibrations and settings

Selected Features for CT subsystem

The X-ray CT alone is a powerful whole-body preclinical imaging system on its own right. Image the largest variety of species in industry including larger animals or a whole body mouse scan in one bed position. Offering a very large detector surface area and large bore with helical scanning possibility, variable zoom (up to 8) and high power X-ray source (up to 80W).

• Broadest range of CT applications: Ultrafast and ultralow dose CT with variable zoom up to 7.6x magnification to visualize even the smallest organs or in-vitro samples up to 120mm FOV
  • Perform a whole-body mouse scan in 2 minutes - have the result instantly with 80 micron voxel size
  • Closest source-object distance for in-vivo: extra small objects imaging
• Tomographic information is ready at the end of scan*: on the fly real time reconstruction is enabled by multi-GPUs (* for general settings)
• Lower X-ray exposure dose to the animals and faster data acquisition due to stronger X-ray tube, increased detector area, sensitivity and better filtering
• Fully automated calibration processes
• Improved safety functions gantry rotation position is stored, X-ray ramp-up and run-up are optimized to ensure prolonged tube

Selected Features for PET subsystem

• Superior PET detector characteristics: Physical performance matches animal imaging performance
  • High-density, ultra-small detectors in tight packing with finest LYSO detector elements in the industry with smallest pitch
  • Increased crystal thickness for highest sensitivity
• Measure even the finest details: Tera-Tomo™ 3D PET reconstruction engine brings PET resolution close to the physical limits with outstanding quantification and better signal recovery and signal-to-noise ratio:
  • Features Monte Carlo system matrix modeling and Depth of Interaction correction; incorporates attenuation, scatter, positron range, random and dead time corrections.
  • Reconstruction running on multiple GPUs (Graphical Processing Units) delivering shorter computational time
• Perform Acquisition and Reconstruction simultaneously with the powerful workstations including DICOM server and multi-modality display and analysis suite

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